v-Agatoxin-IVA and Neuronal N-Type Ca Channels

2026-08-20

Eucommia Leaf Extract Improves Pig Meat Quality

2026-08-20

Wang and colleagues evaluated Eucommia ulmoides leaf extract in finishing pigs using an integrated design that combined antioxidant, meat-quality, muscle-gene, and cecal-microbiota measurements. The study found that extract supplementation, particularly at 0.050%, improved oxidative status and selected pork-quality traits without increasing growth performance, while microbiota changes were associated with health and meat-quality indicators.

Gastrin I: Designing Better GI Organoid Assays

2026-08-19

Gastrin I enables controlled studies of CCK2 receptor signaling, proton pump activation, and gastric acid secretion. This article explains how to select compatible human organoid models and avoid overinterpreting intestinal pharmacokinetic platforms.

Primidone: An Evidence-Calibrated Research Guide

2026-08-19

Primidone, also known as Mysoline, is more than a conventional antiepileptic scaffold. This evidence-calibrated guide connects its TRPM3 and RIPK1 pharmacology with rigorous assay design, translational dosing, and lessons from antimicrobial biofilm research without overstating cross-domain evidence.

HyperScribe T7 High Yield Cy3 RNA Labeling Kit Guide

2026-08-18

Build bright, customizable RNA probes for in situ hybridization and Northern blot workflows with tunable Cy3-UTP incorporation. This practical guide connects probe design and troubleshooting to the MALAT1/miR-125b/STAT3 sepsis study while distinguishing published findings from workflow recommendations.

Nifedipine Research Workflows: Calcium & PXR

2026-08-18

Nifedipine (BAY-a-1040) provides a controllable L-type calcium influx perturbation for cardiac, iron-transport, hepatic, and pathogen assays. This guide translates the reference study’s PXR and CYP findings into practical comparison workflows while clearly separating calcium-channel effects from direct nuclear-receptor activation.

SmD2 Acetylation Links Splicing to PARP Sensitivity

2026-08-17

A 2024 Nature Communications study identifies the spliceosomal protein SmD2 as an acetylation-regulated determinant of BRCA1/FANC cassette-exon expression and PARP inhibitor sensitivity in hepatocellular carcinoma. The findings connect core spliceosome regulation with DNA damage repair and support combining HDAC inhibition with PARP inhibition in selected HCC models.

IWP-2 Workflows for Wnt Production Inhibition

2026-08-17

IWP-2 enables upstream Porcn blockade for studying Wnt-dependent proliferation, invasion, and apoptosis in gastric cancer models. This practical guide also shows how to adapt the inhibitor into cell-type-resolved developmental assays without overstating evidence from neurodevelopmental research.

LDN-193189: Mapping BMP Signals in Cell Plasticity

2026-08-16

Explore how LDN-193189, a selective ALK inhibitor, can separate BMP receptor signaling from TGF-β-driven epithelial plasticity. This article translates mechanistic evidence into assay strategies for stem-cell, barrier, and heterotopic ossification research.

2-Hydroxypropyl-β-cyclodextrin Protocol Guide

2026-08-15

2-Hydroxypropyl-β-cyclodextrin is a water-soluble cyclic oligosaccharide solubilizer for screening poorly water-soluble hydrophobic compounds, particularly molecules containing aromatic or phenyl groups. It is best used as a drug formulation excipient or pharmaceutical solubility improvement aid; the available dossier does not establish therapeutic efficacy or applications outside solubility-focused pharmaceutical and biochemical workflows.

Prenatal Nanoplastics Rewire Vascular Lipid Homeostasis

2026-08-14

A 2026 Cardiovascular Toxicology study shows that prenatal and lactational exposure to polystyrene nanoplastics promotes lipid accumulation in the aortic smooth muscle of male offspring through an MAPK/ERK/UHRF1 axis. The work combines an early-life mouse exposure model with MOVAS-cell experiments, ERK inhibition, and UHRF1 knockdown to connect developmental exposure with vascular lipid dysregulation.

Two Flavone 2′-Glucosides from Scutellaria baicalensis

2026-08-14

Ishimaru and colleagues isolated two previously undescribed flavone 2′-O-glucosides from Scutellaria baicalensis roots and established their structures through chromatography, mass spectrometry, UV, and NMR analysis. The study also documented baicalin methyl ester, an esterified derivative of baicalin, within a broader phenolic profile, providing an important natural-products reference for subsequent intestinal inflammation research.

Trolox Workflows for Oxidative Stress Assays

2026-08-13

Trolox provides a practical antioxidant benchmark for cell-free assays, oxidative injury models, and redox-sensitive organoid experiments. This guide shows how to prepare, deploy, and troubleshoot 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid without confusing antioxidant rescue with improved organoid growth or disease-specific efficacy.

10058-F4: c-Myc-Max Dimerization Inhibitor

2026-08-13

Use 10058-F4 to connect c-Myc/Max disruption with transcriptional, chromatin, viability, apoptosis, and differentiation readouts. This workflow also translates recent TERT findings in human pluripotent stem cells into practical assay designs while keeping formulation and model-specific limitations visible.

TUNEL Apoptosis Detection Kit: Practical Workflows

2026-08-12

Translate DNA fragmentation into a clear brown signal with a DAB-based TUNEL assay for tissue sections and cultured cells. This workflow guide connects oxidative-stress biology, assay controls, image interpretation, and troubleshooting for reproducible programmed cell death research.