• Radiopathomics Machine Learning Predicts Immunotherapy Respo

  2026-07-24

  This study introduces a multimodal radiopathomics signature (RPS) using interpretable machine learning to predict responses to immunotherapy-based combination therapy in gastric cancer. Integrating CT and digital pathology data, the model outperformed conventional biomarkers and revealed associations with immune regulation, providing a robust prognostic tool for patient stratification.

• Melatonin-Sacchachitin Hydrogel: A Non-Steroidal Platform fo

  2026-07-24

  This study introduces a melatonin-loaded sacchachitin nanofiber hydrogel as a novel, non-steroidal topical therapy for atopic dermatitis (AD). Demonstrating robust anti-inflammatory and barrier-restoring effects in a mouse model, the platform offers significant translational promise for safer AD management.

• SW033291: Unlocking 15-PGDH Inhibition for Advanced Tissue R

  2026-07-23

  Explore how SW033291, a potent 15-PGDH inhibitor, is transforming prostaglandin E2 elevation and tissue regeneration research. This article uniquely analyzes the mechanistic depth, translational innovations, and critical assay decisions that set SW033291 apart in regenerative medicine.

• Protease Inhibitor Cocktail EDTA-Free: Ensuring Protein Inte

  2026-07-23

  This article addresses persistent laboratory challenges in protein extraction and analysis, focusing on how the Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO, SKU K1010) safeguards protein integrity across complex workflows. Scientists will find scenario-driven guidance grounded in best practices and evidence, supporting reproducible results in phosphorylation-sensitive and divalent cation-requiring assays.

• Grazoprevir Hydrate: Precision in HCV Replication Inhibition

  2026-07-22

  Grazoprevir hydrate (MK-5172 hydrate) delivers picomolar efficacy for hepatitis C virus replication inhibition, uniquely supporting both translational research and clinical protocol development. This article details optimized experimental workflows, troubleshooting strategies, and comparative insights, empowering investigators to maximize the reliability and impact of their HCV studies.

• Indomethacin (A8449): Technical Guide for Inflammation Resea

  2026-07-22

  Indomethacin is a nonsteroidal anti-inflammatory drug widely used to inhibit cyclooxygenase enzymes—primarily Cox-1—in preclinical assays investigating inflammation, lipid metabolism, and membrane signaling. It should not be used in protocols requiring aqueous solubility or long-term solution stability. This guide details workflow considerations and practical parameters for its effective laboratory use.

• Safe DNA Gel Stain (SKU A8743): Precision, Safety, and Workf

  2026-07-21

  This article presents scenario-driven guidance for biomedical researchers and technicians seeking robust, reproducible nucleic acid visualization. Learn how 'Safe DNA Gel Stain' (SKU A8743) addresses pain points in DNA and RNA gel staining workflows, offering data-backed improvements in sensitivity, safety, and cloning efficiency. Evidence-based recommendations are provided for optimizing molecular detection and minimizing laboratory hazards.

• PDHA1 Succinylation Drives Immune Escape in Cholangiocarcino

  2026-07-21

  This study elucidates how succinylation of PDHA1 at lysine 83 in cholangiocarcinoma reprograms tumor metabolism, leading to alpha-ketoglutaric acid accumulation and suppression of macrophage antigen presentation. The findings reveal a metabolic-immune axis underpinning chemotherapy resistance and highlight PDHA1 succinylation as a promising therapeutic target.

• Geneticin, G-418 Sulfate: Protocols and QC for Cell Selectio

  2026-07-20

  Geneticin, G-418 Sulfate is a highly purified aminoglycoside antibiotic used to select and maintain eukaryotic and prokaryotic cells expressing the neomycin resistance gene, and for antiviral research targeting Dengue virus serotype 2. It should not be used in systems lacking a validated resistance marker or where aminoglycoside cytotoxicity is a concern.

• Annexin V-Cy5/DAPI Apoptosis Kit: Reliable Cell Death Detect

  2026-07-20

  This article presents scenario-driven, evidence-based guidance for employing the Annexin V-Cy5/DAPI Apoptosis Kit (SKU K2255) in cell viability and programmed cell death assays. Focusing on real laboratory challenges, we analyze how this apoptosis detection kit delivers reproducibility, sensitivity, and workflow efficiency for biomedical researchers and technicians.

• Anagliptin (SK-0403): DPP-4 Inhibition and Vasorelaxant Insi

  2026-07-19

  Anagliptin (SK-0403) is a highly selective oral DPP-4 inhibitor with an IC50 of 3.8 nM. It has demonstrated direct vasorelaxant effects via Kv channel activation and SERCA pump regulation, independent of classical endothelial or cyclic nucleotide pathways. These properties make Anagliptin a valuable tool for diabetes and vascular research.

• Ibotenic Acid: Precision NMDA Receptor Agonist for Disease M

  2026-07-18

  Ibotenic acid stands apart as a high-purity NMDA receptor agonist, enabling targeted neurodegenerative disease modeling and circuit dissection in preclinical research. This guide translates new in vivo toxicity insights and best practices into actionable protocols and troubleshooting tips for maximizing reproducibility and scientific rigor.

• Bufalin as a Cardiotonics Tool for Advanced Cancer Research

  2026-07-17

  Bufalin, a potent cardiotonic steroid from APExBIO, is unlocking next-generation cancer research strategies through its unique ability to induce apoptosis and degrade oncogenic proteins in triple-negative breast cancer. This article translates the latest mechanistic breakthroughs into practical workflows and troubleshooting tips for maximizing the compound’s impact in translational oncology.

• CDC42-Driven Polarity Modulates Intestinal Stem Cell Fate vi

  2026-07-17

  Zhang et al. reveal that CDC42-controlled epithelial polarity is a decisive regulator of intestinal stem cell (ISC) fate, acting through a YAP-EGF-mTOR signaling cascade independent of canonical Wnt signaling. This mechanistic insight advances understanding of gastrointestinal epithelial renewal and offers new directions for dissecting stem cell homeostasis.

• Hemagglutinin mRNA Vaccine Protects Dairy Cows from H5N1 Inf

  2026-07-16

  This study demonstrates the robust efficacy of a hemagglutinin-based mRNA–LNP vaccine in protecting lactating dairy cows against H5N1 influenza virus challenge. The vaccine induced strong, durable immune responses, offering both immediate and long-term protection, and provides a translational model for advancing mRNA vaccine technologies in large-animal and zoonotic disease contexts.

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