• Although the amino acid sequences of CUL A and CUL

  2021-07-22

  

  Although the amino phenanthroline sequences of CUL4A and CUL4B share 82% identity, the existing studies have shown that these two proteins do not have significant functional redundancy. Elevated expression of CUL4A has been observed in a variety of cancer cells, such as breast cancer, ovarian cance

• The Rev protein is a crucial regulator of

  2021-07-22

  

  The Rev1 protein is a crucial regulator of TLS activity because of its structural function [10]; therefore, we focused on Rev1 to investigate how Dot1/Rad53 function impinges on TLS-dependent mutagenic bypass of MMS-induced lesions. In particular, we examined Rev1 localization to chromatin by immuno

• br Structural and biochemical features of pol

  2021-07-22

  

  Structural and biochemical features of pol X family polymerases The X-family DNA polymerase (polX) is specialized in DNA repair. This family is composed of four different DNA polymerases: pol β, pol λ, pol μ and TdT. Only three members of the polX family possess an N-terminal BRCT (BRCA1 carboxy-

• We therefore propose a scenario based on our experimental

  2021-07-21

  

  We therefore propose a scenario based on our experimental models and depicted schematically in Figure 7. In fully respiring cells, CI, CII, and DHODH transfer electrons to CoQ, which are then forwarded to CIII. This latter complex transfers electrons to CIV, which then produces water at the expense

• In a recent study Tomkins et al

  2021-07-21

  

  In a recent study, Tomkins et al. [7] analyzed the protein-protein interaction network of ROCO proteins. Based on a database analysis, and only taking into account interactions reported in at least two peer-reviewed papers and/or confirmed by two different methods, 113 interactors were revealed for

• To date little is known

  2021-07-21

  

  To date, little is known about the regulation of PCD through phytocystatin inhibitory activity. Inhibitors that may regulate leaf senescence (Huang et al., 2001, Tajima et al., 2011) or may inhibit PCD induced by abiotic factors, such as mechanical tissue damage or oxidative stress caused by cold (B

• In this review we first introduce the in vivo

  2021-07-21

  

  In this review, we first introduce the in vivo metabolism profile of VD3, and the mediation of Cyp3a gene transcription by PXR and CAR in humans, mice and rats. We then focus on the species-specific VDR-dependent regulation of human (CYP3A4, CYP3A5 and CYP3A7), mouse (mainly CYP3A11 and CYP3A13), an

• br Author contribution br Acknowledgements QNRF grant number

  2021-07-21

  

  Author contribution Acknowledgements QNRF grant number NPRP6-065-3-012, Qatar National Research Fund, Doha Qatar for funding this work with grant number NPRP No.: NPRP6-065-3-012. Introduction Preeclampsia (PE) affects 3–5 % of pregnancies worldwide and is one of the leading causes of mate

• Epitope analyses of AT AA and ET AA indicate that

  2021-07-21

  

  Epitope analyses of AT1-AA and ET-AA indicate that the AG-14361 of both autoantibodies are located at the second extracelluar loop of both receptors. The specific epitopes for both autoantibodies are similar to what was reported previously in a cohort of patients from Brazil [6] and for AT1-AA also

• The need for dedicated DAPT updates is well justified

  2021-07-21

  

  The need for dedicated DAPT updates is well justified by the large amount of data and new information generated in the field over the past few years. As expected, the ACC/AHA and ESC updates contain large areas of overlap as well as some differences. Differences were largely explained by the differe

• br Thy nephritis is one of the most

  2021-07-21

  

  Thy1.1 nephritis is one of the most commonly used models to study the course of immunoglobulin A and other mesangioproliferative nephropathies. To date, most of the studies have focused on mesangial and, to a lesser extent, endothelial cell recovery following capillary damage, whereas data concern

• PGE EP activation has been found

  2021-07-21

  

  PGE2-EP4 activation has been found to attenuate the activation of microglia and to prevent lipid peroxidation and pro-inflammatory gene expression in a murine model of lipopolysaccharide (LPS)-induced TC-I 15 inflammation [15]. Moreover, PGE2/EP4 signaling has elicited a protective function in reduc

• br Conflict of interest br Acknowledgements This

  2021-07-21

  

  Conflict of interest Acknowledgements This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (2013R1A1A1076117) and also by the Priority Research Centers Program through the NRF funde

• In the context of E ligase drug

  2021-07-20

  

  In the context of E3 ligase drug discovery, it is critical to identify the appropriate E2/E3 substrate pairing to ensure the development and use of the most physiologically relevant screening assay. There have been many reports of limited E2/E3 activity profiling with a small number of E2 and E3 Gem

• Z-WEHD-FMK br Materials and methods br Results

  2021-07-20

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important Z-WEHD-FMK of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation syst

14325 records 596/955 page Previous Next First page 上5页 596597598599600 下5页 Last page